Strega Nona has something on her mind. Lately she is distracted and she almost gave Signore Mayor the wrong remedy for his headache. One night Strega Nona has a dream about her Grandma Concetta, who has been in heaven for many years, and her little house at the seashore. Nona decides that she will take a vacation there. While Strega Nona is away, Bambolona will do the daily remedies and Big Anthony will do the chores. And with these two left in charge, what could possibly go wrong?